Assay Detail
Functional
CHEMBL4179601
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Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis H37Rv INH-R1 harboring katG Y155 mutant after 5 days
63
Total Activities
23
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 23 | - | - |
| IC90 | 20 | - | - |
| IC50 | 20 | 4.53 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4202551 | — | — | 3 | 5.35 |
| CHEMBL4213380 | — | — | 3 | 5.07 |
| CHEMBL3633321 | — | — | 3 | 5.05 |
| CHEMBL4217594 | — | — | 3 | 4.60 |
| CHEMBL4209908 | — | — | 3 | 4.54 |
| CHEMBL3612341 | — | — | 3 | 4.51 |
| CHEMBL3410623 | — | — | 3 | 4.50 |
| CHEMBL3633320 | — | — | 3 | 4.50 |
| CHEMBL3612343 | — | — | 3 | 4.48 |
| CHEMBL3410626 | — | — | 3 | 4.47 |
| CHEMBL4206147 | — | — | 3 | 4.42 |
| CHEMBL3633322 | — | — | 3 | 4.32 |
| CHEMBL3612338 | — | — | 3 | 4.27 |
| CHEMBL3612837 | — | — | 3 | 4.19 |
| CHEMBL3612337 | — | — | 3 | 4.14 |
| CHEMBL3612346 | — | — | 3 | 4.12 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | - |
| CHEMBL64 | ISONIAZID | 4.0 | 1 | - |
| CHEMBL3358487 | — | — | 3 | - |
| CHEMBL5315124 | LEVOFLOXACIN | 4.0 | 1 | - |
| CHEMBL3612347 | — | — | 3 | - |
| CHEMBL4208967 | — | — | 3 | - |
| CHEMBL3358488 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4202551 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4213380 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3633321 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4217594 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4209908 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3612341 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3410623 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3633320 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3612343 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3410626 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4206147 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3633322 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3612338 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL3612837 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3612337 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL3612346 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3358488 | — | IC50 | - | — | - | |
| CHEMBL3358488 | — | IC90 | - | — | - | |
| CHEMBL4208967 | — | IC50 | - | — | - | |
| CHEMBL4208967 | — | IC90 | - | — | - | |
| CHEMBL3612341 | — | MIC | = | 48000.0 | nM | - |
| CHEMBL3358487 | — | IC50 | - | — | - | |
| CHEMBL3358487 | — | MIC | = | 7500.0 | nM | - |
| CHEMBL3358488 | — | MIC | = | 11100.0 | nM | - |
| CHEMBL3410623 | — | IC90 | = | 47000.0 | nM | - |
| CHEMBL3410623 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL3612338 | — | IC90 | = | 76000.0 | nM | - |
| CHEMBL3612338 | — | MIC | = | 91000.0 | nM | - |
| CHEMBL3612337 | — | IC90 | = | 130000.0 | nM | - |
| CHEMBL3612337 | — | MIC | = | 125000.0 | nM | - |
| CHEMBL3612343 | — | IC90 | = | 47000.0 | nM | - |
| CHEMBL3612343 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL3612341 | — | IC90 | = | 43000.0 | nM | - |
| CHEMBL3633320 | — | IC90 | = | 44000.0 | nM | - |
| CHEMBL3612346 | — | MIC | > | 200000.0 | nM | - |
| CHEMBL3612346 | — | IC90 | = | 140000.0 | nM | - |
| CHEMBL3612837 | — | MIC | > | 200000.0 | nM | - |
| CHEMBL3612347 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3612837 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3612347 | — | MIC | > | 200000.0 | nM | - |
| CHEMBL3612347 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL4209908 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL5315124 | LEVOFLOXACIN | MIC | = | 1100.0 | nM | - |
| CHEMBL3633320 | — | MIC | = | 48000.0 | nM | - |
| CHEMBL3633321 | — | IC90 | = | 14000.0 | nM | - |
| CHEMBL3633321 | — | MIC | = | 14000.0 | nM | - |
| CHEMBL3633322 | — | IC90 | = | 82000.0 | nM | - |
| CHEMBL3633322 | — | MIC | = | 79000.0 | nM | - |
| CHEMBL64 | ISONIAZID | MIC | > | 200000.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | MIC | = | 12.0 | nM | - |