Assay Detail
Binding
CHEMBL4182004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and antidepressant activity of a series of arylalkanol and aralkyl piperazine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.63 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.54 |
| CHEMBL4209430 | — | — | 1 | 7.00 |
| CHEMBL4203932 | — | — | 1 | 6.47 |
| CHEMBL4217086 | — | — | 1 | 6.23 |
| CHEMBL4215605 | — | — | 1 | 6.08 |
| CHEMBL4211687 | — | — | 1 | 6.06 |
| CHEMBL4205570 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2104993 | VORTIOXETINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4209430 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4203932 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4217086 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4215605 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4211687 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4205570 | — | IC50 | = | 950.0 | nM | 6.02 |