Assay Detail
Functional
CHEMBL4183759
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Antitrypanosomal activity against trypomastigote form of Trypanosoma brucei Squib 427 assessed as parasite growth inhibition after 72 hrs by resazurin assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.40 |
| CHEMBL4210475 | — | — | 1 | 5.26 |
| CHEMBL4204999 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4210475 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4204999 | — | IC50 | = | 6700.0 | nM | 5.17 |