Assay Detail
Functional
CHEMBL4184876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A2780 cells after 4 days by CellTiter-Glo assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208619 | — | — | 1 | 9.00 |
| CHEMBL4203945 | — | — | 1 | 9.00 |
| CHEMBL4209341 | — | — | 1 | 9.00 |
| CHEMBL4207982 | — | — | 1 | 8.70 |
| CHEMBL4204004 | — | — | 1 | 8.52 |
| CHEMBL4211212 | — | — | 1 | 8.40 |
| CHEMBL4217456 | — | — | 1 | 8.30 |
| CHEMBL4215840 | — | — | 1 | 8.30 |
| CHEMBL4213004 | — | — | 1 | 8.15 |
| CHEMBL4209227 | — | — | 1 | 8.10 |
| CHEMBL4209447 | — | — | 1 | 8.10 |
| CHEMBL4212358 | — | — | 1 | 7.92 |
| CHEMBL4213810 | — | — | 1 | 7.85 |
| CHEMBL4204746 | — | — | 1 | 7.85 |
| CHEMBL4217940 | — | — | 1 | 7.82 |
| CHEMBL4202544 | — | — | 1 | 7.66 |
| CHEMBL4205098 | — | — | 1 | 7.57 |
| CHEMBL4210641 | — | — | 1 | 7.52 |
| CHEMBL4211401 | — | — | 1 | 7.37 |
| CHEMBL4206641 | — | — | 1 | 7.00 |
| CHEMBL4206515 | — | — | 1 | 6.70 |
| CHEMBL4216041 | — | — | 1 | 6.47 |
| CHEMBL4214006 | — | — | 1 | 6.39 |
| CHEMBL4210753 | — | — | 1 | 6.20 |
| CHEMBL4210883 | — | — | 1 | 6.08 |
| CHEMBL4215893 | — | — | 1 | - |
| CHEMBL4211993 | — | — | 1 | - |
| CHEMBL4215088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208619 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4203945 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4209341 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4207982 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4204004 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4211212 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4217456 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4215840 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4213004 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4209227 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4209447 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4212358 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4213810 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4204746 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4217940 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4202544 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4205098 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4210641 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4211401 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4206641 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4206515 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4216041 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4214006 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL4210753 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4210883 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL4215893 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL4211993 | — | IC50 | - | — | - | |
| CHEMBL4215088 | — | IC50 | > | 10000.0 | nM | - |