Assay Detail

CHEMBL4185225

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi at 5 uM by Alamar Blue assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Trypanosoma cruzi (CHEMBL368) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Trypanosoma cruzi (CHEMBL368) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma cruzi

CHEMBL368

Anchored from Assay target.

Protein identity Trypanosoma cruzi

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma cruzi
Confidence	1 — Organism
Curated By	Intermediate

Target

Trypanosoma cruzi (CHEMBL368) ↗

Type	ORGANISM
Organism	Trypanosoma cruzi

Publication

Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.

Hailu GS, Robaa D, Forgione M, Sippl W, Rotili D, Mai A.
J Med Chem (2017) 60 : 4780 -4804
PubMed 28241112 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	4.97	4.97

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL597845	SALERMIDE	—	1	4.97
CHEMBL1140	NIACINAMIDE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL597845	SALERMIDE	EC50	=	10600.0	nM	4.97
CHEMBL1140	NIACINAMIDE	EC50	=	25800000.0	nM	-