Assay Detail
Binding
CHEMBL4190749
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Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.14 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440765 | U-69593 | — | 1 | 9.01 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.16 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.46 |
| CHEMBL4212604 | — | — | 1 | 6.88 |
| CHEMBL4215892 | — | — | 1 | 6.54 |
| CHEMBL4206082 | — | — | 1 | 6.04 |
| CHEMBL4203694 | — | — | 1 | 5.89 |
| CHEMBL4216136 | — | — | 1 | - |
| CHEMBL4203850 | — | — | 1 | - |
| CHEMBL4209225 | — | — | 1 | - |
| CHEMBL4218965 | — | — | 1 | - |
| CHEMBL4216717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440765 | U-69593 | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL80 | NALOXONE | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL70 | MORPHINE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL4212604 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL4215892 | — | Ki | = | 286.0 | nM | 6.54 |
| CHEMBL4206082 | — | Ki | = | 912.0 | nM | 6.04 |
| CHEMBL4203694 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL4216136 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4203850 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4209225 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4218965 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4216717 | — | Ki | > | 1000.0 | nM | - |