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Assay Detail

CHEMBL4190750

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Brain
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mu-type opioid receptor (CHEMBL4354)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Medchemcomm (2016) 7 : 2368 -2380
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 7.09 8.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL80 NALOXONE 4.0 1 8.68
CHEMBL70 MORPHINE 4.0 1 8.41
CHEMBL4206082 1 6.58
CHEMBL4218965 1 6.35
CHEMBL4216717 1 6.30
CHEMBL4209225 1 6.20
CHEMBL4216136 1 -
CHEMBL4203850 1 -
CHEMBL4203694 1 -
CHEMBL4215892 1 -
CHEMBL4212604 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL80 NALOXONE Ki = 2.1 nM 8.68
CHEMBL70 MORPHINE Ki = 3.9 nM 8.41
CHEMBL4206082 Ki = 261.0 nM 6.58
CHEMBL4218965 Ki = 447.0 nM 6.35
CHEMBL4216717 Ki = 502.0 nM 6.30
CHEMBL4209225 Ki = 633.0 nM 6.20
CHEMBL4216136 Ki > 1000.0 nM -
CHEMBL4203850 Ki > 1000.0 nM -
CHEMBL4203694 Ki > 1000.0 nM -
CHEMBL4215892 Ki > 1000.0 nM -
CHEMBL4212604 Ki > 1000.0 nM -