Assay Detail
Functional
CHEMBL4191473
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Antiparasitic activity against trophozoite stage of Trichomonas vaginalis CNCD 147 after 48 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trichomonas vaginalis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.01 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4210015 | — | — | 1 | 7.92 |
| CHEMBL4217508 | — | — | 1 | 7.88 |
| CHEMBL4212043 | — | — | 1 | 7.55 |
| CHEMBL4202744 | — | — | 1 | 7.54 |
| CHEMBL4206155 | — | — | 1 | 7.39 |
| CHEMBL4205808 | — | — | 1 | 7.17 |
| CHEMBL4203032 | — | — | 1 | 6.95 |
| CHEMBL4208693 | — | — | 1 | 6.92 |
| CHEMBL4216112 | — | — | 1 | 6.89 |
| CHEMBL4213092 | — | — | 1 | 6.79 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 6.63 |
| CHEMBL4214402 | — | — | 1 | 6.43 |
| CHEMBL4213631 | — | — | 1 | 6.29 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4210015 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4217508 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL4212043 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL4202744 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL4206155 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4205808 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL4203032 | — | IC50 | = | 111.4 | nM | 6.95 |
| CHEMBL4208693 | — | IC50 | = | 119.9 | nM | 6.92 |
| CHEMBL4216112 | — | IC50 | = | 127.8 | nM | 6.89 |
| CHEMBL4213092 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL4214402 | — | IC50 | = | 367.6 | nM | 6.43 |
| CHEMBL4213631 | — | IC50 | = | 515.3 | nM | 6.29 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 1590.5 | nM | 5.80 |