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Compound Detail

CHEMBL4203032

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CSc1nc2cc(C(=O)Nc3cccc(C)n3)c(Cl)cc2[nH]1

Basic Information

ChEMBL ID CHEMBL4203032
Phase Preclinical
Structure Type MOL
InChI Key YIZMNZXYHJDZAX-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

332.8
MW (Da)
3.89
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.71
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H13ClN4OS
MW 332.82
Aromatic Rings 3
Heavy Atoms 22
NP-Likeness -2.33

Activity Summary

IC50 3 meas. best 7.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Entamoeba histolytica
CHEMBL612853
IC50 7.09 7.09 81.3 1
Trichomonas vaginalis
CHEMBL612884
IC50 6.95 6.95 111.4 1
Giardia intestinalis
CHEMBL612652
IC50 6.87 6.87 135.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28595066 10.1016/j.ejmech.2017.05.058 Giardia intestinalis 1
28595066 10.1016/j.ejmech.2017.05.058 Trichomonas vaginalis 1
28595066 10.1016/j.ejmech.2017.05.058 Entamoeba histolytica 1

Data from ChEMBL 36 via Core Engine