Assay Detail
Functional
CHEMBL4191479
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Antiparasitic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS after 48 hrs by haemocytometric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.26 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228258 | — | — | 1 | 7.30 |
| CHEMBL226656 | — | — | 1 | 6.68 |
| CHEMBL226921 | — | — | 1 | 6.64 |
| CHEMBL227370 | — | — | 1 | 6.52 |
| CHEMBL389272 | — | — | 1 | 6.36 |
| CHEMBL228199 | — | — | 1 | 5.88 |
| CHEMBL226920 | — | — | 1 | 5.81 |
| CHEMBL3220678 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228258 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL226656 | — | IC50 | = | 208.93 | nM | 6.68 |
| CHEMBL226921 | — | IC50 | = | 229.09 | nM | 6.64 |
| CHEMBL227370 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL389272 | — | IC50 | = | 436.52 | nM | 6.36 |
| CHEMBL228199 | — | IC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL226920 | — | IC50 | = | 1548.82 | nM | 5.81 |
| CHEMBL3220678 | — | IC50 | = | 13803.84 | nM | 4.86 |