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Compound Detail

CHEMBL226920

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O=[N+]([O-])c1cc2nc(C(F)(F)F)[nH]c2cc1[N+](=O)[O-]

Basic Information

ChEMBL ID CHEMBL226920
Phase Preclinical
Structure Type MOL
InChI Key OOJCWFWANPATNU-UHFFFAOYSA-N
3
Targets
8
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

276.1
MW (Da)
2.40
ALogP
5
HBA
1
HBD
115.0
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H3F3N4O4
MW 276.13
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -1.27

Activity Summary

IC50 8 meas. best 6.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 6.62 6.62 239.9 3
Trichomonas vaginalis
CHEMBL612884
IC50 6.24 6.24 575.4 3
Entamoeba histolytica
CHEMBL612853
IC50 5.87 5.84 1349.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17074492 10.1016/j.bmc.2006.10.019 Entamoeba histolytica 1
20888242 10.1016/j.bmc.2010.09.019 Trichomonas vaginalis 1
20888242 10.1016/j.bmc.2010.09.019 Giardia intestinalis 1
- 10.1039/C0MD00159G Trichomonas vaginalis 1
- 10.1039/C0MD00159G Giardia intestinalis 1
28595066 10.1016/j.ejmech.2017.05.058 Giardia intestinalis 1
28595066 10.1016/j.ejmech.2017.05.058 Entamoeba histolytica 1
28595066 10.1016/j.ejmech.2017.05.058 Trichomonas vaginalis 1

Data from ChEMBL 36 via Core Engine