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Assay Detail

CHEMBL915565

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Functional
Antiamnesic activity against Entamoeba histolytica
ChEMBL ↗
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Entamoeba histolytica
Confidence 1 — Organism
Curated By Intermediate

Target

Entamoeba histolytica (CHEMBL612853) ↗
Type ORGANISM
Organism Entamoeba histolytica

Publication

Molecular modeling of some 1H-benzimidazole derivatives with biological activity against Entamoeba histolytica: a comparative molecular field analysis study.
López-Vallejo F, Medina-Franco JL, Hernández-Campos A, Rodríguez-Morales S, Yépez L, Cedillo R, Castillo R.
Bioorg Med Chem (2007) 15 : 1117 -1126
PubMed 17074492 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 7.05 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL224742 — — 1 8.30
CHEMBL69086 — — 1 8.30
CHEMBL227086 — — 1 8.22
CHEMBL309135 — — 1 8.15
CHEMBL376814 — — 1 8.00
CHEMBL227688 — — 1 7.89
CHEMBL53788 — — 1 7.66
CHEMBL71855 — — 1 7.60
CHEMBL54544 — — 1 7.48
CHEMBL227807 — — 1 7.43
CHEMBL374624 — — 1 7.43
CHEMBL69098 — — 1 7.41
CHEMBL293520 — — 1 7.40
CHEMBL306226 BENZIMIDAZOLE -1.0 1 7.38
CHEMBL56473 — — 1 7.34
CHEMBL228258 — — 1 7.30
CHEMBL71706 — — 1 7.26
CHEMBL71905 — — 1 7.23
CHEMBL227936 — — 1 7.21
CHEMBL55641 — — 1 7.16
CHEMBL72244 — — 1 7.08
CHEMBL303252 — — 1 7.02
CHEMBL305513 — — 1 6.94
CHEMBL269158 — — 1 6.90
CHEMBL227863 — — 1 6.89
CHEMBL70141 2-MERCAPTOBENZIMIDAZOLE — 1 6.88
CHEMBL71936 — — 1 6.72
CHEMBL223968 — — 1 6.71
CHEMBL387631 — — 1 6.69
CHEMBL226656 — — 1 6.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL224742 — IC50 = 5.012 nM 8.30
CHEMBL69086 — IC50 = 5.012 nM 8.30
CHEMBL227086 — IC50 = 6.026 nM 8.22
CHEMBL309135 — IC50 = 7.079 nM 8.15
CHEMBL376814 — IC50 = 10.0 nM 8.00
CHEMBL227688 — IC50 = 12.88 nM 7.89
CHEMBL53788 — IC50 = 21.88 nM 7.66
CHEMBL71855 — IC50 = 25.12 nM 7.60
CHEMBL54544 — IC50 = 33.11 nM 7.48
CHEMBL227807 — IC50 = 37.15 nM 7.43
CHEMBL374624 — IC50 = 37.15 nM 7.43
CHEMBL69098 — IC50 = 38.9 nM 7.41
CHEMBL293520 — IC50 = 39.81 nM 7.40
CHEMBL306226 BENZIMIDAZOLE IC50 = 41.69 nM 7.38
CHEMBL56473 — IC50 = 45.71 nM 7.34
CHEMBL228258 — IC50 = 50.12 nM 7.30
CHEMBL71706 — IC50 = 54.95 nM 7.26
CHEMBL71905 — IC50 = 58.88 nM 7.23
CHEMBL227936 — IC50 = 61.66 nM 7.21
CHEMBL55641 — IC50 = 69.18 nM 7.16
CHEMBL72244 — IC50 = 83.18 nM 7.08
CHEMBL303252 — IC50 = 95.5 nM 7.02
CHEMBL305513 — IC50 = 114.82 nM 6.94
CHEMBL269158 — IC50 = 125.89 nM 6.90
CHEMBL227863 — IC50 = 128.82 nM 6.89
CHEMBL70141 2-MERCAPTOBENZIMIDAZOLE IC50 = 131.83 nM 6.88
CHEMBL71936 — IC50 = 190.55 nM 6.72
CHEMBL223968 — IC50 = 194.98 nM 6.71
CHEMBL387631 — IC50 = 204.17 nM 6.69
CHEMBL226656 — IC50 = 208.93 nM 6.68
CHEMBL226921 — IC50 = 213.8 nM 6.67
CHEMBL227739 — IC50 = 245.47 nM 6.61
CHEMBL227370 — IC50 = 302.0 nM 6.52
CHEMBL67822 — IC50 = 354.81 nM 6.45
CHEMBL72355 — IC50 = 389.05 nM 6.41
CHEMBL389272 — IC50 = 426.58 nM 6.37
CHEMBL227687 — IC50 = 575.44 nM 6.24
CHEMBL389269 — IC50 = 1047.13 nM 5.98
CHEMBL228199 — IC50 = 1318.26 nM 5.88
CHEMBL226920 — IC50 = 1348.96 nM 5.87
CHEMBL227686 — IC50 = 3801.89 nM 5.42