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Compound Detail

CHEMBL228199

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FC(F)(F)c1nc2cc(Br)ccc2[nH]1

Basic Information

ChEMBL ID CHEMBL228199
Phase Preclinical
Structure Type MOL
InChI Key FKSDCMMCSWXZLS-UHFFFAOYSA-N
3
Targets
8
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

265.0
MW (Da)
3.34
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.78
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H4BrF3N2
MW 265.03
Aromatic Rings 2
Heavy Atoms 14
NP-Likeness -1.49

Activity Summary

IC50 8 meas. best 6.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 6.19 6.19 645.6 3
Entamoeba histolytica
CHEMBL612853
IC50 5.88 5.88 1318.3 2
Trichomonas vaginalis
CHEMBL612884
IC50 5.8 5.8 1584.9 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C0MD00159G Trichomonas vaginalis 2
- 10.1039/C0MD00159G Giardia intestinalis 2
17074492 10.1016/j.bmc.2006.10.019 Entamoeba histolytica 1
28595066 10.1016/j.ejmech.2017.05.058 Giardia intestinalis 1
28595066 10.1016/j.ejmech.2017.05.058 Entamoeba histolytica 1
28595066 10.1016/j.ejmech.2017.05.058 Trichomonas vaginalis 1

Data from ChEMBL 36 via Core Engine