Assay Detail
Binding
CHEMBL4193443
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Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 180 secs by spectrophotometric analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.26 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4203538 | — | — | 1 | 5.83 |
| CHEMBL4214951 | — | — | 1 | 5.64 |
| CHEMBL4217212 | — | — | 1 | 5.62 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.54 |
| CHEMBL4203653 | — | — | 1 | 5.48 |
| CHEMBL4214755 | — | — | 1 | 5.48 |
| CHEMBL4208392 | — | — | 1 | 5.46 |
| CHEMBL3917990 | — | — | 1 | 5.43 |
| CHEMBL4207876 | — | — | 1 | 5.35 |
| CHEMBL4204053 | — | — | 1 | 5.28 |
| CHEMBL4218997 | — | — | 1 | 5.28 |
| CHEMBL4204899 | — | — | 1 | 5.28 |
| CHEMBL4212229 | — | — | 1 | 5.22 |
| CHEMBL4215324 | — | — | 1 | 5.09 |
| CHEMBL3978533 | — | — | 1 | 5.09 |
| CHEMBL3891025 | — | — | 1 | 5.06 |
| CHEMBL3970226 | — | — | 1 | 5.02 |
| CHEMBL4216806 | — | — | 1 | 5.01 |
| CHEMBL75121 | — | — | 1 | 4.91 |
| CHEMBL4207272 | — | — | 1 | 4.86 |
| CHEMBL4203519 | — | — | 1 | 4.86 |
| CHEMBL4215728 | — | — | 1 | 4.86 |
| CHEMBL32749 | FERULATE | -1.0 | 1 | - |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4203538 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4214951 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4217212 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL4203653 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4214755 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL4208392 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL3917990 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL4207876 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4204053 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL4218997 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL4204899 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4212229 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL4215324 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL3978533 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL3891025 | — | IC50 | = | 8780.0 | nM | 5.06 |
| CHEMBL3970226 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4216806 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL75121 | — | IC50 | = | 12360.0 | nM | 4.91 |
| CHEMBL4207272 | — | IC50 | = | 13920.0 | nM | 4.86 |
| CHEMBL4203519 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4215728 | — | IC50 | = | 13950.0 | nM | 4.86 |
| CHEMBL32749 | FERULATE | IC50 | - | — | - | |
| CHEMBL165 | RESVERATROL | IC50 | - | — | - | |
| CHEMBL140 | CURCUMIN | IC50 | - | — | - |