Assay Detail
Binding
CHEMBL4193537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p110delta/p85alpha (unknown origin) using PIP2 as substrate by HTRF colorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.06 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207150 | — | — | 1 | 7.16 |
| CHEMBL1765463 | — | — | 1 | 7.06 |
| CHEMBL4213353 | — | — | 1 | 7.03 |
| CHEMBL4207685 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207150 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1765463 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4213353 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4207685 | — | IC50 | = | 101.0 | nM | 7.00 |