Assay Detail
Binding
CHEMBL4193569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Kv1.3 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 3 (CHEMBL4633) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.30 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444449 | — | — | 1 | 7.62 |
| CHEMBL4207745 | — | — | 1 | 5.85 |
| CHEMBL3621636 | — | — | 1 | 5.60 |
| CHEMBL397591 | OROIDIN | — | 1 | 5.33 |
| CHEMBL4210636 | — | — | 1 | 5.05 |
| CHEMBL3261431 | — | — | 1 | 4.85 |
| CHEMBL4208517 | — | — | 1 | 4.77 |
| CHEMBL3261430 | — | — | 1 | 4.68 |
| CHEMBL4213446 | — | — | 1 | 4.60 |
| CHEMBL4202870 | — | — | 1 | 4.60 |
| CHEMBL465679 | CLATHRODIN | — | 1 | - |
| CHEMBL4206278 | — | — | 1 | - |
| CHEMBL4211159 | — | — | 1 | - |
| CHEMBL4203801 | — | — | 1 | - |
| CHEMBL4208681 | — | — | 1 | - |
| CHEMBL4207090 | — | — | 1 | - |
| CHEMBL4218820 | — | — | 1 | - |
| CHEMBL4211453 | — | — | 1 | - |
| CHEMBL4215589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444449 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4207745 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3621636 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL397591 | OROIDIN | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4210636 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3261431 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4208517 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3261430 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4213446 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4202870 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL465679 | CLATHRODIN | IC50 | > | 30000.0 | nM | - |
| CHEMBL4206278 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4211159 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4203801 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4208681 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4207090 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4218820 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4211453 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4215589 | — | IC50 | > | 30000.0 | nM | - |