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Compound Detail

CHEMBL3261431

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Nc1nc(/C=C/CNC(=O)c2cc3cc(F)ccc3[nH]2)c[nH]1

Basic Information

ChEMBL ID CHEMBL3261431
Phase Preclinical
Structure Type MOL
InChI Key HFMHYLCYABPWMX-OWOJBTEDSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

299.3
MW (Da)
2.06
ALogP
3
HBA
4
HBD
99.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H14FN5O
MW 299.31
Aromatic Rings 3
Heavy Atoms 22
NP-Likeness -0.44

Activity Summary

IC50 3 meas. best 5.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Potassium voltage-gated channel subfamily A member 6
CHEMBL5279
IC50 5.1 5.1 7900.0 1
Potassium voltage-gated channel subfamily A member 4
CHEMBL4205
IC50 5.06 5.06 8800.0 1
Potassium voltage-gated channel subfamily A member 3
CHEMBL4633
IC50 4.85 4.85 14000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24755428 10.1016/j.bmcl.2014.03.094 Staphylococcus aureus 2
24755428 10.1016/j.bmcl.2014.03.094 Streptococcus mutans 2
28802123 10.1016/j.ejmech.2017.08.015 Potassium voltage-gated channel subfamily A member 1 2
28802123 10.1016/j.ejmech.2017.08.015 Potassium voltage-gated channel subfamily A member 2 2
28802123 10.1016/j.ejmech.2017.08.015 Potassium voltage-gated channel subfamily A member 3 2
28802123 10.1016/j.ejmech.2017.08.015 Potassium voltage-gated channel subfamily A member 4 2
28802123 10.1016/j.ejmech.2017.08.015 Potassium voltage-gated channel subfamily A member 5 2
28802123 10.1016/j.ejmech.2017.08.015 Potassium voltage-gated channel subfamily A member 6 2
24755428 10.1016/j.bmcl.2014.03.094 Pseudomonas aeruginosa 1
- 10.1039/C4MD00286E HepG2 1
28802123 10.1016/j.ejmech.2017.08.015 Voltage-gated delayed rectifier potassium channel KCNH1 1

Data from ChEMBL 36 via Core Engine