Assay Detail
Binding
CHEMBL4193572
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Inhibition of human Kv1.6 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 6 (CHEMBL5279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.23 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444449 | — | — | 1 | 6.89 |
| CHEMBL4207745 | — | — | 1 | 5.80 |
| CHEMBL3621636 | — | — | 1 | 5.43 |
| CHEMBL397591 | OROIDIN | — | 1 | 5.31 |
| CHEMBL3261431 | — | — | 1 | 5.10 |
| CHEMBL4213446 | — | — | 1 | 4.96 |
| CHEMBL3261430 | — | — | 1 | 4.85 |
| CHEMBL4202870 | — | — | 1 | 4.77 |
| CHEMBL4210636 | — | — | 1 | 4.62 |
| CHEMBL4208517 | — | — | 1 | 4.54 |
| CHEMBL465679 | CLATHRODIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444449 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4207745 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3621636 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL397591 | OROIDIN | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3261431 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4213446 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3261430 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4202870 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4210636 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4208517 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL465679 | CLATHRODIN | IC50 | > | 30000.0 | nM | - |