Assay Detail
Functional
CHEMBL4194169
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Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes assessed as induction of parasite lysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.54 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112481 | VERAGUENSIN | — | 1 | 5.64 |
| CHEMBL459404 | GRANDISIN | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112481 | VERAGUENSIN | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL459404 | GRANDISIN | EC50 | = | 3700.0 | nM | 5.43 |