Assay Detail
Functional
CHEMBL4195797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of BAFF-stimulated marginal zone B cell survival in C57BL/6 mouse assessed as plasma concentration required for reduction in CD23-low cell survival at 100 to 200 mg/kg, po administered twice daily for 7 days by flow cytometry
3
Total Activities
1
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.43 | 6.43 |
| IC70 | 1 | - | - |
| IC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4211840 | — | — | 3 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4211840 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL4211840 | — | IC70 | = | 0.915 | uM | - |
| CHEMBL4211840 | — | IC90 | = | 3853.0 | nM | - |