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Assay Detail

CHEMBL4196334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of thrombin (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The selectivity and bioavailability improvement of novel oral anticoagulants: An overview.
Xie Z, Tian Y, Lv X, Xiao X, Zhan M, Cheng K, Li S, Liao C.
Eur J Med Chem (2018) 146 : 299 -317
PubMed 29407959 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 8.77 10.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL143418 1 10.38
CHEMBL143024 1 8.64
CHEMBL282837 1 8.64
CHEMBL29019 1 8.54
CHEMBL29657 1 8.51
CHEMBL141889 1 8.38
CHEMBL30054 DPOC-4088 1.0 1 8.28
CHEMBL104951 1 -
CHEMBL327265 1 -
CHEMBL320172 1 -
CHEMBL103461 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL143418 Ki = 0.042 nM 10.38
CHEMBL143024 Ki = 2.3 nM 8.64
CHEMBL282837 Ki = 2.3 nM 8.64
CHEMBL29019 Ki = 2.9 nM 8.54
CHEMBL29657 Ki = 3.1 nM 8.51
CHEMBL141889 Ki = 4.2 nM 8.38
CHEMBL30054 DPOC-4088 Ki = 5.2 nM 8.28
CHEMBL104951 Ki < 0.01 nM -
CHEMBL327265 Ki < 0.01 nM -
CHEMBL320172 Ki = 0.0015 nM -
CHEMBL103461 Ki = 0.0014 nM -