Assay Detail
Functional
CHEMBL4197327
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Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTS assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 6.00 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4202862 | — | — | 1 | 6.89 |
| CHEMBL4208987 | — | — | 1 | 6.85 |
| CHEMBL4207736 | — | — | 1 | 6.80 |
| CHEMBL4205081 | — | — | 1 | 6.62 |
| CHEMBL4206146 | — | — | 1 | 6.60 |
| CHEMBL4214770 | — | — | 1 | 6.58 |
| CHEMBL4211153 | — | — | 1 | 6.57 |
| CHEMBL4207887 | — | — | 1 | 6.52 |
| CHEMBL4211852 | — | — | 1 | 6.48 |
| CHEMBL4215055 | — | — | 1 | 6.47 |
| CHEMBL4211587 | — | — | 1 | 6.44 |
| CHEMBL4218733 | — | — | 1 | 6.43 |
| CHEMBL4211559 | — | — | 1 | 6.43 |
| CHEMBL4214959 | — | — | 1 | 6.39 |
| CHEMBL4203389 | — | — | 1 | 6.39 |
| CHEMBL4214392 | — | — | 1 | 6.37 |
| CHEMBL4206450 | — | — | 1 | 6.25 |
| CHEMBL1208572 | SALINOMYCIN | 2.0 | 1 | 6.24 |
| CHEMBL4210467 | — | — | 1 | 6.21 |
| CHEMBL4217329 | — | — | 1 | 6.17 |
| CHEMBL4211443 | — | — | 1 | 6.16 |
| CHEMBL4203645 | — | — | 1 | 6.14 |
| CHEMBL4216538 | — | — | 1 | 6.09 |
| CHEMBL4216954 | — | — | 1 | 6.04 |
| CHEMBL4210628 | — | — | 1 | 5.99 |
| CHEMBL4212997 | — | — | 1 | 5.99 |
| CHEMBL4208800 | — | — | 1 | 5.92 |
| CHEMBL4209051 | — | — | 1 | 5.90 |
| CHEMBL4210429 | — | — | 1 | 5.89 |
| CHEMBL4208836 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4202862 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4208987 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4207736 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4205081 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4206146 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4214770 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4211153 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4207887 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4211852 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4215055 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4211587 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4218733 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4211559 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4214959 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4203389 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4214392 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4206450 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1208572 | SALINOMYCIN | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4210467 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4217329 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4211443 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4203645 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4216538 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4216954 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4212997 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4210628 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4208800 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4209051 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4210429 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4208836 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4210923 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4214202 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4210193 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4215881 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4208264 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4218810 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4204467 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4206558 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4216133 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4202729 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL4207012 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL4214915 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4210001 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4203919 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4204180 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4216173 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL4207082 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL4212899 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4215059 | — | IC50 | = | 18260.0 | nM | 4.74 |
| CHEMBL4213192 | — | IC50 | > | 20000.0 | nM | - |