Assay Detail
Functional
CHEMBL4198679
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Antiproliferative activity against human Jurkat cells after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.59 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.16 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.46 |
| CHEMBL2170177 | — | — | 1 | 5.35 |
| CHEMBL4218377 | — | — | 1 | 5.10 |
| CHEMBL4218674 | — | — | 1 | 4.91 |
| CHEMBL4206936 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2170177 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4218377 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4218674 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4206936 | — | IC50 | = | 28400.0 | nM | 4.55 |