Assay Detail
Binding
CHEMBL4201008
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Inhibition of ACK1 (unknown origin) by radiometric biochemical kinase assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.64 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207036 | — | — | 1 | 8.22 |
| CHEMBL4214342 | — | — | 1 | 8.10 |
| CHEMBL4213673 | — | — | 1 | 8.05 |
| CHEMBL4212150 | — | — | 1 | 8.00 |
| CHEMBL4212663 | — | — | 1 | 7.96 |
| CHEMBL4202685 | — | — | 1 | 7.89 |
| CHEMBL4215916 | — | — | 1 | 7.82 |
| CHEMBL459850 | — | — | 1 | 7.75 |
| CHEMBL4209948 | — | — | 1 | 7.70 |
| CHEMBL4212809 | — | — | 1 | 7.70 |
| CHEMBL4217421 | — | — | 1 | 7.70 |
| CHEMBL4209082 | — | — | 1 | 7.68 |
| CHEMBL4213019 | — | — | 1 | 7.68 |
| CHEMBL4215989 | — | — | 1 | 7.68 |
| CHEMBL4203337 | — | — | 1 | 7.64 |
| CHEMBL4207753 | — | — | 1 | 7.60 |
| CHEMBL1214141 | — | — | 1 | 7.60 |
| CHEMBL4216786 | — | — | 1 | 7.60 |
| CHEMBL4218831 | — | — | 1 | 7.58 |
| CHEMBL4207100 | — | — | 1 | 7.58 |
| CHEMBL4211976 | — | — | 1 | 7.55 |
| CHEMBL4214863 | — | — | 1 | 7.55 |
| CHEMBL4210482 | — | — | 1 | 7.46 |
| CHEMBL4213945 | — | — | 1 | 7.44 |
| CHEMBL1214142 | — | — | 1 | 7.43 |
| CHEMBL4206139 | — | — | 1 | 7.40 |
| CHEMBL4205942 | — | — | 1 | 7.40 |
| CHEMBL4211880 | — | — | 1 | 7.28 |
| CHEMBL4211395 | — | — | 1 | 7.22 |
| CHEMBL4210185 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207036 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4214342 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4213673 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4212150 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4212663 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4202685 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4215916 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL459850 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4209948 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4212809 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4217421 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4209082 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4213019 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4215989 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4203337 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4207753 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1214141 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4216786 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4218831 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4207100 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4211976 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4214863 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4210482 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4213945 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1214142 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4206139 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4205942 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4211880 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4211395 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4210185 | — | IC50 | = | 94.0 | nM | 7.03 |