Assay Detail
Binding
CHEMBL4202305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Trypanosoma brucei brucei alternative oxidase using ubiquinol-1 as substrate incubated for 2 mins followed by substrate addition by spectrophotometric method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei brucei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Alternative oxidase, mitochondrial (CHEMBL4295594) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei |
Publication
SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.77 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133046 | ASCOFURANONE | — | 1 | 8.70 |
| CHEMBL4216944 | — | — | 1 | 8.51 |
| CHEMBL4213740 | — | — | 1 | 8.38 |
| CHEMBL4203629 | — | — | 1 | 8.04 |
| CHEMBL4205799 | — | — | 1 | 7.92 |
| CHEMBL4215836 | — | — | 1 | 7.82 |
| CHEMBL4204231 | — | — | 1 | 7.14 |
| CHEMBL4218963 | — | — | 1 | 6.60 |
| CHEMBL4209637 | — | — | 1 | 6.13 |
| CHEMBL4203618 | — | — | 1 | 6.04 |
| CHEMBL4210869 | — | — | 1 | 5.96 |
| CHEMBL4216658 | — | — | 1 | 5.91 |
| CHEMBL4218759 | — | — | 1 | 5.77 |
| CHEMBL4215825 | — | — | 1 | 5.68 |
| CHEMBL4209094 | — | — | 1 | 5.64 |
| CHEMBL4215285 | — | — | 1 | 5.62 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 5.23 |
| CHEMBL4208808 | — | — | 1 | - |
| CHEMBL4214233 | — | — | 1 | - |
| CHEMBL4214550 | — | — | 1 | - |
| CHEMBL4211387 | — | — | 1 | - |
| CHEMBL4218451 | — | — | 1 | - |
| CHEMBL4207025 | — | — | 1 | - |
| CHEMBL4206705 | — | — | 1 | - |
| CHEMBL4218131 | — | — | 1 | - |
| CHEMBL4213204 | — | — | 1 | - |
| CHEMBL4205256 | — | — | 1 | - |
| CHEMBL4212516 | — | — | 1 | - |
| CHEMBL4207610 | — | — | 1 | - |
| CHEMBL4209349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133046 | ASCOFURANONE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4216944 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4213740 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4203629 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4205799 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4215836 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4204231 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4218963 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4209637 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4203618 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4210869 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4216658 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4218759 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4215825 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4209094 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4215285 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL4204981 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4204480 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4216427 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4204751 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4211974 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4209349 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4207610 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4212516 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4205256 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4213204 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4218131 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4206705 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4207025 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4218451 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4211387 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4214550 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4214233 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4208808 | — | IC50 | > | 5000.0 | nM | - |