Assay Detail
Functional
CHEMBL4202306
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Antiparasitic activity against bloodstream trypomastigote stage of wild type Trypanosoma brucei brucei Lister 427 after 48 hrs by resazurin dye based fluorescence assay
28
Total Activities
28
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.39 | 8.70 |
| Activity | 2 | - | - |
| MIC | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205256 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.38 |
| CHEMBL4213740 | — | — | 1 | 7.89 |
| CHEMBL4214550 | — | — | 1 | 7.75 |
| CHEMBL4215836 | — | — | 1 | 7.75 |
| CHEMBL4205799 | — | — | 1 | 7.55 |
| CHEMBL4218131 | — | — | 1 | 7.43 |
| CHEMBL4218963 | — | — | 1 | 7.30 |
| CHEMBL4209637 | — | — | 1 | 7.30 |
| CHEMBL4206705 | — | — | 1 | 7.07 |
| CHEMBL4209349 | — | — | 1 | 6.80 |
| CHEMBL4213204 | — | — | 1 | 6.72 |
| CHEMBL4204480 | — | — | 1 | 6.54 |
| CHEMBL4218451 | — | — | 1 | 6.14 |
| CHEMBL4216658 | — | — | 1 | 5.76 |
| CHEMBL4208808 | — | — | 1 | 5.62 |
| CHEMBL4211974 | — | — | 1 | 5.18 |
| CHEMBL4216427 | — | — | 1 | 5.09 |
| CHEMBL4204751 | — | — | 1 | 5.05 |
| CHEMBL4204981 | — | — | 1 | 4.97 |
| CHEMBL4212516 | — | — | 1 | 4.77 |
| CHEMBL4204231 | — | — | 1 | 4.75 |
| CHEMBL4207610 | — | — | 1 | 4.71 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 4.20 |
| CHEMBL4204553 | — | — | 1 | - |
| CHEMBL4210453 | — | — | 1 | - |
| CHEMBL4211387 | — | — | 1 | - |
| CHEMBL133046 | ASCOFURANONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205256 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4213740 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4214550 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4215836 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4205799 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4218131 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4218963 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4209637 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4206705 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4209349 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4213204 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4204480 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4218451 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4216658 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4208808 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4211974 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4216427 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4204751 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4204981 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4212516 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4204231 | — | EC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4207610 | — | EC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | EC50 | = | 62900.0 | nM | 4.20 |
| CHEMBL4204553 | — | Activity | - | — | - | |
| CHEMBL4210453 | — | Activity | - | — | - | |
| CHEMBL4211387 | — | EC50 | - | — | - | |
| CHEMBL133046 | ASCOFURANONE | MIC | = | 250000.0 | nM | - |