Assay Detail
Binding
CHEMBL4219694
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Binding affinity to human SERT expressed in HEK293 cells after 60 mins in presence of [3H]imipramine by liquid scintillation counting
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.06 | 8.68 |
| Kd | 1 | 6.68 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227444 | — | — | 2 | 8.68 |
| CHEMBL4226233 | — | — | 1 | 8.22 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 7.41 |
| CHEMBL4228171 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227444 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4226233 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4227444 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL637 | VENLAFAXINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL4228171 | — | Kd | = | 210.0 | nM | 6.68 |