Assay Detail
Functional
CHEMBL4219780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.36 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9941 | — | — | 1 | 5.20 |
| CHEMBL227779 | — | — | 1 | 4.86 |
| CHEMBL4225885 | — | — | 1 | 4.54 |
| CHEMBL4226932 | — | — | 1 | 4.45 |
| CHEMBL4225814 | — | — | 1 | 4.26 |
| CHEMBL4228628 | — | — | 1 | 4.08 |
| CHEMBL4225790 | — | — | 1 | 4.07 |
| CHEMBL4228917 | — | — | 1 | 4.06 |
| CHEMBL4226089 | — | — | 1 | 4.03 |
| CHEMBL4228155 | — | — | 1 | 4.00 |
| CHEMBL4226075 | — | — | 1 | - |
| CHEMBL4227122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9941 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL227779 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4225885 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4226932 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL4225814 | — | IC50 | = | 54800.0 | nM | 4.26 |
| CHEMBL4228628 | — | IC50 | = | 82300.0 | nM | 4.08 |
| CHEMBL4225790 | — | IC50 | = | 84900.0 | nM | 4.07 |
| CHEMBL4228917 | — | IC50 | = | 86800.0 | nM | 4.06 |
| CHEMBL4226089 | — | IC50 | = | 92500.0 | nM | 4.03 |
| CHEMBL4228155 | — | IC50 | = | 99300.0 | nM | 4.00 |
| CHEMBL4226075 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4227122 | — | IC50 | > | 100000.0 | nM | - |