Assay Detail
Binding
CHEMBL4220344
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSF1R (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Advances of Colony-Stimulating Factor-1 Receptor (CSF-1R) Kinase and Its Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.99 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227505 | SOTULETINIB | 2.0 | 1 | 8.92 |
| CHEMBL3674570 | EDICOTINIB | 2.0 | 1 | 8.49 |
| CHEMBL4225509 | — | — | 1 | 8.26 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 7.89 |
| CHEMBL261849 | GW632580X | — | 1 | 7.22 |
| CHEMBL4228766 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227505 | SOTULETINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3674570 | EDICOTINIB | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4225509 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL261849 | GW632580X | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4228766 | — | IC50 | = | 69.0 | nM | 7.16 |