Compound Detail
CHEMBL261849
GW632580X Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL261849 |
| Name | GW632580X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MYQAUKPBNJWPIE-UHFFFAOYSA-N |
11
Targets
54
Activities
3
Assay Types
4
PK Parameters
20
Publications
0
Known Names
Molecular Properties
366.4
MW (Da)
2.83
ALogP
7
HBA
2
HBD
105.5
PSA (Ų)
0.66
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 38 meas. best 8.52
Kd 12 meas. best 8.8
Ki 4 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | Kd | 8.8 | 8.7067 | 1.6 | 3 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 8.52 | 6.3648 | 3.0 | 29 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL5570 | IC50 | 8.0 | 7.205 | 10.0 | 2 |
| BDNF/NT-3 growth factors receptor CHEMBL4898 | Kd | 7.44 | 7.44 | 36.0 | 3 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | Ki | 7.4 | 7.4 | 39.8 | 1 |
| NT-3 growth factor receptor CHEMBL5608 | Kd | 6.92 | 6.92 | 120.0 | 3 |
| BDNF/NT-3 growth factors receptor CHEMBL4898 | Ki | 6.8 | 6.8 | 158.5 | 1 |
| NT-3 growth factor receptor CHEMBL5608 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 6.48 | 6.48 | 330.0 | 1 |
| Monocyte CHEMBL614076 | IC50 | 6.33 | 6.33 | 470.0 | 1 |
| High affinity nerve growth factor receptor CHEMBL2815 | Kd | 6.2 | 6.2 | 630.0 | 3 |
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 6.06 | 6.06 | 880.0 | 1 |
| High affinity nerve growth factor receptor CHEMBL2815 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| HUVEC CHEMBL613979 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
| NSO CHEMBL615003 | IC50 | 4.87 | 4.87 | 13500.0 | 1 |
| BT-474 CHEMBL614529 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
| HN5 CHEMBL614828 | IC50 | 4.54 | 4.54 | 29000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 1400.0 | nM | Mus musculus |
| Cmax | 5600.0 | nM | Mus musculus |
| Cmax | 50.0 | nM | Mus musculus |
| Cmax | 400.0 | nM | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16249345 | 10.1073/pnas.0502000102 | Unchecked | 31 |
| 16249345 | 10.1073/pnas.0502000102 | Mus musculus | 21 |
| 22037378 | 10.1038/nbt.1990 | Tyrosine-protein kinase ABL1 | 15 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL5444388 | Macrophage colony-stimulating factor 1 receptor | 13 |
| 16249345 | 10.1073/pnas.0502000102 | Osteoclast | 13 |
| 22037378 | 10.1038/nbt.1990 | Epidermal growth factor receptor | 12 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| 22037378 | 10.1038/nbt.1990 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 10 |
| - | 10.6019/CHEMBL4689842 | U2OS | 10 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| 18183025 | 10.1038/nbt1358 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 10 |
| 26254279 | 10.18632/oncotarget.4214 | Macrophage colony-stimulating factor 1 receptor | 9 |
| - | 10.6019/CHEMBL5303304 | Fibroblast | 9 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| 22037378 | 10.1038/nbt.1990 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL4689842 | HEK-293T | 8 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
Data from ChEMBL 36 via Core Engine