Assay Detail
Binding
CHEMBL4220744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured for 45 mins by Ellmans microplate assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.39 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.48 |
| CHEMBL601724 | — | — | 1 | 5.30 |
| CHEMBL4227873 | — | — | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL601724 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL4227873 | — | IC50 | - | — | - | |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |