Assay Detail
Binding
CHEMBL4222673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PIM2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.44 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4229130 | — | — | 1 | 6.85 |
| CHEMBL4228654 | — | — | 1 | 5.85 |
| CHEMBL4224859 | — | — | 1 | 5.55 |
| CHEMBL4228363 | — | — | 1 | 5.16 |
| CHEMBL4227817 | — | — | 1 | 5.07 |
| CHEMBL4225287 | — | — | 1 | 5.00 |
| CHEMBL4227886 | — | — | 1 | 4.58 |
| CHEMBL4227556 | — | — | 1 | - |
| CHEMBL4227028 | — | — | 1 | - |
| CHEMBL4225330 | — | — | 1 | - |
| CHEMBL4225224 | — | — | 1 | - |
| CHEMBL4224959 | — | — | 1 | - |
| CHEMBL4228394 | — | — | 1 | - |
| CHEMBL4224693 | — | — | 1 | - |
| CHEMBL4225206 | — | — | 1 | - |
| CHEMBL4227791 | — | — | 1 | - |
| CHEMBL4225896 | — | — | 1 | - |
| CHEMBL4225046 | — | — | 1 | - |
| CHEMBL4225633 | — | — | 1 | - |
| CHEMBL4224786 | — | — | 1 | - |
| CHEMBL4225378 | — | — | 1 | - |
| CHEMBL4228564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4229130 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4228654 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4224859 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4228363 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4227817 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4225287 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4227886 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4227556 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4227028 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4225330 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4225224 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4224959 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4228394 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4224693 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4225206 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4227791 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4225896 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4225046 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4225633 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4224786 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4225378 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4228564 | — | IC50 | > | 30000.0 | nM | - |