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Assay Detail

CHEMBL4223183

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei 427 bloodstream forms assessed as parasitic growth inhibition after 48 hrs by alamar blue assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent.
Zhang H, Collins J, Nyamwihura R, Ware S, Kaiser M, Ogungbe IV.
Bioorg Med Chem Lett (2018) 28 : 1647 -1651
PubMed 29609908 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.56 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL265502 SURAMIN 3.0 1 8.40
CHEMBL4227913 1 6.12
CHEMBL4229077 1 5.83
CHEMBL4228757 1 5.70
CHEMBL4228375 1 5.66
CHEMBL4225326 1 5.52
CHEMBL4228815 1 5.39
CHEMBL4227061 1 5.26
CHEMBL4225851 1 5.25
CHEMBL4227859 1 5.25
CHEMBL4224731 1 5.22
CHEMBL4226632 1 5.22
CHEMBL4225785 1 5.15
CHEMBL4228686 1 5.14
CHEMBL4228113 1 4.97
CHEMBL4227256 1 4.93
CHEMBL4225585 1 -
CHEMBL4227591 1 -
CHEMBL4228424 1 -
CHEMBL4224995 1 -
CHEMBL4225052 1 -
CHEMBL4227321 1 -
CHEMBL4228160 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL265502 SURAMIN IC50 = 4.0 nM 8.40
CHEMBL4227913 IC50 = 760.0 nM 6.12
CHEMBL4229077 IC50 = 1470.0 nM 5.83
CHEMBL4228757 IC50 = 2010.0 nM 5.70
CHEMBL4228375 IC50 = 2180.0 nM 5.66
CHEMBL4225326 IC50 = 3040.0 nM 5.52
CHEMBL4228815 IC50 = 4040.0 nM 5.39
CHEMBL4227061 IC50 = 5450.0 nM 5.26
CHEMBL4225851 IC50 = 5630.0 nM 5.25
CHEMBL4227859 IC50 = 5620.0 nM 5.25
CHEMBL4224731 IC50 = 6040.0 nM 5.22
CHEMBL4226632 IC50 = 5970.0 nM 5.22
CHEMBL4225785 IC50 = 7030.0 nM 5.15
CHEMBL4228686 IC50 = 7160.0 nM 5.14
CHEMBL4228113 IC50 = 10770.0 nM 4.97
CHEMBL4227256 IC50 = 11720.0 nM 4.93
CHEMBL4225585 IC50 > 20000.0 nM -
CHEMBL4227591 IC50 > 20000.0 nM -
CHEMBL4228424 IC50 > 20000.0 nM -
CHEMBL4224995 IC50 > 20000.0 nM -
CHEMBL4225052 IC50 > 20000.0 nM -
CHEMBL4227321 IC50 > 20000.0 nM -
CHEMBL4228160 IC50 > 20000.0 nM -