Assay Detail
Binding
CHEMBL4229775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ACE using Hip-His-Leu-OH as substrate after 1 hr by fluorimetric method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.79 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.20 |
| CHEMBL4248427 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4248427 | — | IC50 | = | 43.0 | nM | 7.37 |