Assay Detail
Functional
CHEMBL4231098
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Anti-parasitic activity against bloodstream trypomastigote stage of Trypanosoma brucei brucei with AQP triple knock out after 48 hrs by resazurin-based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.10 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4249714 | — | — | 1 | 9.43 |
| CHEMBL477683 | PHENYLARSINE OXIDE | — | 1 | 8.89 |
| CHEMBL4245918 | — | — | 1 | 8.85 |
| CHEMBL4250711 | — | — | 1 | 8.30 |
| CHEMBL4244022 | — | — | 1 | 7.52 |
| CHEMBL4247258 | — | — | 1 | 7.28 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.19 |
| CHEMBL4237349 | — | — | 1 | 7.07 |
| CHEMBL4237238 | — | — | 1 | 5.97 |
| CHEMBL4239171 | — | — | 1 | 5.90 |
| CHEMBL4247810 | — | — | 1 | 5.75 |
| CHEMBL4240979 | — | — | 1 | 5.74 |
| CHEMBL4090897 | — | — | 1 | 5.33 |
| CHEMBL4069905 | — | — | 1 | 5.29 |
| CHEMBL4250174 | — | — | 1 | 5.17 |
| CHEMBL4237659 | — | — | 1 | 5.16 |
| CHEMBL4241528 | — | — | 1 | 5.15 |
| CHEMBL4248268 | — | — | 1 | 5.14 |
| CHEMBL4237726 | — | — | 1 | 5.10 |
| CHEMBL4241091 | — | — | 1 | 5.05 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 5.05 |
| CHEMBL4244828 | — | — | 1 | 5.03 |
| CHEMBL4251018 | — | — | 1 | 4.92 |
| CHEMBL4245303 | — | — | 1 | 4.83 |
| CHEMBL4068891 | — | — | 1 | 4.81 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | — | 1 | 4.78 |
| CHEMBL4249095 | — | — | 1 | - |
| CHEMBL4241625 | — | — | 1 | - |
| CHEMBL4243481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4249714 | — | EC50 | = | 0.37 | nM | 9.43 |
| CHEMBL477683 | PHENYLARSINE OXIDE | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4245918 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4250711 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4244022 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4247258 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4237349 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4237238 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4239171 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4247810 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4240979 | — | EC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4090897 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4069905 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4250174 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4237659 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4241528 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4248268 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4237726 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4241091 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4244828 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4251018 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4245303 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4068891 | — | EC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | EC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4249095 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL4241625 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL4243481 | — | EC50 | = | 400000.0 | nM | - |