Assay Detail
Binding
CHEMBL4233278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate by pyruvate kinase-lactate dehydrogenase coupled assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.09 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4237479 | — | — | 1 | 8.00 |
| CHEMBL4251324 | — | — | 1 | 7.89 |
| CHEMBL4241204 | — | — | 1 | 7.35 |
| CHEMBL4240949 | — | — | 1 | 7.33 |
| CHEMBL4245507 | — | — | 1 | 7.29 |
| CHEMBL3581121 | — | — | 1 | 7.08 |
| CHEMBL4241689 | — | — | 1 | 7.06 |
| CHEMBL4249314 | — | — | 1 | 6.66 |
| CHEMBL4241299 | — | — | 1 | 6.62 |
| CHEMBL4248852 | — | — | 1 | 6.37 |
| CHEMBL4242549 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4237479 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4251324 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4241204 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL4240949 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL4245507 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL3581121 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL4241689 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL4249314 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4241299 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4248852 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL4242549 | — | Ki | = | 510.0 | nM | 6.29 |