Assay Detail
Functional
CHEMBL4235452
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Antimigratory activity in human THP1 cells assessed as inhibition of MCP-1 mediated cell migration after 1 hr by ATP luciferase based luminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.35 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4242191 | — | — | 1 | 7.85 |
| CHEMBL4248525 | — | — | 1 | 7.77 |
| CHEMBL4245242 | — | — | 1 | 7.75 |
| CHEMBL4249925 | — | — | 1 | 7.66 |
| CHEMBL4245197 | — | — | 1 | 7.62 |
| CHEMBL4240458 | — | — | 1 | 7.34 |
| CHEMBL4238696 | — | — | 1 | 7.24 |
| CHEMBL4250547 | — | — | 1 | 7.21 |
| CHEMBL4244717 | — | — | 1 | 7.19 |
| CHEMBL4241305 | — | — | 1 | 7.01 |
| CHEMBL4237255 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4242191 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4248525 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4245242 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4249925 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4245197 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4240458 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4238696 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4250547 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4244717 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4241305 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4237255 | — | IC50 | = | 580.0 | nM | 6.24 |