Assay Detail
Binding
CHEMBL4235821
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Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.61 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL964 | DISULFIRAM | 4.0 | 1 | 7.03 |
| CHEMBL120563 | THIRAM | 2.0 | 1 | 6.96 |
| CHEMBL1618272 | — | — | 1 | 6.77 |
| CHEMBL4245637 | — | — | 1 | 5.89 |
| CHEMBL4240937 | — | — | 1 | 5.68 |
| CHEMBL4238380 | — | — | 1 | 5.30 |
| CHEMBL4237334 | — | — | 1 | 5.30 |
| CHEMBL1356238 | PYRITHIONE | 4.0 | 1 | 4.92 |
| CHEMBL4241062 | — | — | 1 | 4.92 |
| CHEMBL1927732 | — | — | 1 | 4.75 |
| CHEMBL4242081 | — | — | 1 | 4.24 |
| CHEMBL4241417 | — | — | 1 | - |
| CHEMBL4251179 | — | — | 1 | - |
| CHEMBL3144916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL964 | DISULFIRAM | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL120563 | THIRAM | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1618272 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4245637 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4240937 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4238380 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4237334 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1356238 | PYRITHIONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4241062 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1927732 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4242081 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4241417 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4251179 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3144916 | — | IC50 | > | 100000.0 | nM | - |