Assay Detail
Functional
CHEMBL4236736
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Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.35 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4242118 | — | — | 1 | 5.12 |
| CHEMBL4245151 | — | — | 1 | 4.85 |
| CHEMBL4103458 | — | — | 1 | 4.60 |
| CHEMBL4241012 | — | — | 1 | 4.60 |
| CHEMBL4237970 | — | — | 1 | 4.40 |
| CHEMBL4249395 | — | — | 1 | 4.39 |
| CHEMBL4242301 | — | — | 1 | 4.16 |
| CHEMBL4248565 | — | — | 1 | 4.15 |
| CHEMBL4242768 | — | — | 1 | 4.14 |
| CHEMBL4243204 | — | — | 1 | 4.08 |
| CHEMBL4239018 | — | — | 1 | 4.05 |
| CHEMBL2179435 | — | — | 1 | 4.00 |
| CHEMBL4251139 | — | — | 1 | 4.00 |
| CHEMBL4237338 | — | — | 1 | - |
| CHEMBL4246646 | — | — | 1 | - |
| CHEMBL4245651 | — | — | 1 | - |
| CHEMBL4238095 | — | — | 1 | - |
| CHEMBL4247378 | — | — | 1 | - |
| CHEMBL4243136 | — | — | 1 | - |
| CHEMBL4245293 | — | — | 1 | - |
| CHEMBL4242223 | — | — | 1 | - |
| CHEMBL4244211 | — | — | 1 | - |
| CHEMBL4244893 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4242118 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4245151 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4103458 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4241012 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4237970 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4249395 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4242301 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4248565 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4242768 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4243204 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL4239018 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL2179435 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4251139 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4237338 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL4246646 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL4245651 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL4238095 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL4247378 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL4243136 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL4245293 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL4242223 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL4244211 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL4244893 | — | IC50 | = | 160000.0 | nM | - |