Assay Detail
Binding
CHEMBL4251841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 JH2 domain in IL23-stimulated human Kit225 T cells by luciferase reporter assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of imidazo[1,2-<i>b</i>]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.22 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285841 | — | — | 1 | 7.70 |
| CHEMBL4287761 | — | — | 1 | 7.16 |
| CHEMBL4279157 | — | — | 1 | 7.00 |
| CHEMBL4293907 | — | — | 1 | 6.96 |
| CHEMBL4295039 | — | — | 1 | 6.82 |
| CHEMBL4279883 | — | — | 1 | 6.62 |
| CHEMBL4291200 | — | — | 1 | 6.52 |
| CHEMBL4289426 | — | — | 1 | 6.52 |
| CHEMBL4291611 | — | — | 1 | 6.48 |
| CHEMBL4293510 | — | — | 1 | 6.39 |
| CHEMBL4278757 | — | — | 1 | 6.32 |
| CHEMBL4283351 | — | — | 1 | 6.29 |
| CHEMBL4287081 | — | — | 1 | 6.22 |
| CHEMBL4285755 | — | — | 1 | 6.16 |
| CHEMBL4290130 | — | — | 1 | 6.11 |
| CHEMBL4287153 | — | — | 1 | 6.00 |
| CHEMBL4293619 | — | — | 1 | 5.96 |
| CHEMBL4281304 | — | — | 1 | 5.92 |
| CHEMBL4289875 | — | — | 1 | 5.85 |
| CHEMBL4283724 | — | — | 1 | 5.47 |
| CHEMBL4286006 | — | — | 1 | 5.31 |
| CHEMBL4282627 | — | — | 1 | 5.21 |
| CHEMBL4285530 | — | — | 1 | 5.14 |
| CHEMBL4289149 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285841 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4287761 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4279157 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4293907 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4295039 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4279883 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4291200 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4289426 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4291611 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4293510 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4278757 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4283351 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4287081 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4285755 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4290130 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4287153 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4293619 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4281304 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4289875 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4283724 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4286006 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4282627 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4285530 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4289149 | — | IC50 | = | 8200.0 | nM | 5.09 |