Compound Detail
CHEMBL4285755
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Basic Information
| ChEMBL ID | CHEMBL4285755 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IGYJLYHJRAPGFK-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
2.76
ALogP
6
HBA
3
HBD
97.3
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Non-receptor tyrosine-protein kinase TYK2 CHEMBL3553 | IC50 | 7.66 | 6.5567 | 22.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Non-receptor tyrosine-protein kinase TYK2 | IC50 | = | 22.0 | nM | 7.66 | Displacement of [3H]-(R)-N-(1-(3-(8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thia... | 30108788 |
| Non-receptor tyrosine-protein kinase TYK2 | IC50 | = | 700.0 | nM | 6.16 | Inhibition of TYK2 JH2 domain in IL23-stimulated human Kit225 T cells by lucifer... | 30108788 |
| Non-receptor tyrosine-protein kinase TYK2 | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of TYK2 JH2 domain in IFNalpha-stimulated human Kit225 T cells by luc... | 30108788 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30108788 | 10.1039/C6MD00560H | Non-receptor tyrosine-protein kinase TYK2 | 4 |
| 30108788 | 10.1039/C6MD00560H | Tyrosine-protein kinase JAK1 | 1 |
| 30108788 | 10.1039/C6MD00560H | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine