Assay Detail
Binding
CHEMBL4252136
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Displacement of [3H]DADLE from delta-opioid receptor in rat brain membranes after 2 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective kappa opioid antagonists for treatment of addiction, are we there yet?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.21 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575508 | — | — | 1 | 6.21 |
| CHEMBL2112474 | — | — | 1 | - |
| CHEMBL2112472 | — | — | 1 | - |
| CHEMBL415247 | JDTIC | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575508 | — | Ki | = | 616.0 | nM | 6.21 |
| CHEMBL2112474 | — | Ki | > | 3400.0 | nM | - |
| CHEMBL2112472 | — | Ki | > | 4900.0 | nM | - |
| CHEMBL415247 | JDTIC | Ki | > | 300.0 | nM | - |