Assay Detail
Functional
CHEMBL4254484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PMA-induced human THP1 monocytes differentiation in to macrophages preincubated for 6 hrs followed by PMA stimulation by phase contrast microscopic method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.45 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4279764 | — | — | 1 | 6.89 |
| CHEMBL4285920 | — | — | 1 | 5.91 |
| CHEMBL4289748 | — | — | 1 | 5.32 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 5.31 |
| CHEMBL4290032 | — | — | 1 | 5.25 |
| CHEMBL4279346 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4279764 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4285920 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4289748 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL4290032 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL4279346 | — | IC50 | = | 99390.0 | nM | 4.00 |