Assay Detail
Binding
CHEMBL4254595
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Inhibition of serotonin reuptake in SERT (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and antidepressant-like activity of novel aralkyl piperazine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.88 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124069 | — | — | 1 | 9.33 |
| CHEMBL4289361 | — | — | 1 | 7.60 |
| CHEMBL4204665 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124069 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL4289361 | — | Ki | = | 25.3 | nM | 7.60 |
| CHEMBL4204665 | — | Ki | = | 195.02 | nM | 6.71 |