Assay Detail
Binding
CHEMBL4254774
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Inhibition of Influenza A virus (A/WSN/1933(H1N1)) neuraminidase pre-incubated for 10 mins before 4-MUNANA substrate addition by fluorometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/WSN/1933(H1N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Neuraminidase (CHEMBL1287610) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) |
Publication
Peramivir conjugates as orally available agents against influenza H275Y mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.15 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288789 | — | — | 1 | 9.36 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 9.32 |
| CHEMBL4285430 | — | — | 1 | 9.19 |
| CHEMBL4278125 | — | — | 1 | 9.17 |
| CHEMBL4293261 | — | — | 1 | 9.03 |
| CHEMBL4280263 | — | — | 1 | 9.00 |
| CHEMBL4288995 | — | — | 1 | 8.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288789 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL4285430 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL4278125 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL4293261 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL4280263 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL4288995 | — | IC50 | = | 1.05 | nM | 8.98 |