Assay Detail
Binding
CHEMBL4254784
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Inhibition of Influenza A virus (A/Vietnam/1194/2004 (H5N1)) recombinant neuraminidase E119A mutant expressed in HEK293 cells pre-incubated for 10 mins before 4-MUNANA substrate addition by fluorometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Brisbane/10/2007(H3N2)) |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Peramivir conjugates as orally available agents against influenza H275Y mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.28 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 6.35 |
| CHEMBL4288789 | — | — | 1 | 6.25 |
| CHEMBL4288995 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL4288789 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL4288995 | — | IC50 | = | 590.0 | nM | 6.23 |