Assay Detail
Functional
CHEMBL4256492
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Antiviral activity against thymidine kinase expressing Varicella-Zoster virus Oka assessed as inhibition of plaque formation measured after 5 days post-infection
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 8.48 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287637 | — | — | 1 | 9.35 |
| CHEMBL4279732 | — | — | 1 | 9.33 |
| CHEMBL4289210 | — | — | 1 | 9.28 |
| CHEMBL4294880 | — | — | 1 | 9.24 |
| CHEMBL4285119 | — | — | 1 | 9.24 |
| CHEMBL4292630 | — | — | 1 | 8.85 |
| CHEMBL4289474 | — | — | 1 | 8.82 |
| CHEMBL4280917 | — | — | 1 | 8.70 |
| CHEMBL4288817 | — | — | 1 | 8.59 |
| CHEMBL4278559 | — | — | 1 | 7.48 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.28 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.55 |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287637 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL4279732 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4289210 | — | EC50 | = | 0.52 | nM | 9.28 |
| CHEMBL4294880 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL4285119 | — | EC50 | = | 0.57 | nM | 9.24 |
| CHEMBL4292630 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4289474 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4280917 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4288817 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4278559 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL1540 | PENCICLOVIR | EC50 | - | — | - | |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - | |
| CHEMBL5314375 | CIDOFOVIR | EC50 | - | — | - |