Assay Detail
Functional
CHEMBL4256633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antinociceptive activity in po dosed FVB hSCN9a Tg inherited erythromelalgia mouse model expressing human NaV1.7 I848T mutant assessed as inhibition of aconitine-induced pain administered 2 hr prior to aconitine challenge measured for 30 mins
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.40 | 6.30 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290579 | — | — | 1 | 6.30 |
| CHEMBL4279238 | — | — | 2 | 5.24 |
| CHEMBL4285790 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290579 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4279238 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4285790 | — | EC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL4279238 | — | Inhibition | - | % | - |