Assay Detail
Binding
CHEMBL4256952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal His-tagged JMJD2A (1 to 350 residues) expressed in Escherichia coli using H3K9me3-biotin peptide as substrate after 30 mins in presence of alpha-ketoglutaric acid by LANCE TR-FRET assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Histone demethylase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.71 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287561 | — | — | 1 | 7.00 |
| CHEMBL4288884 | — | — | 1 | 7.00 |
| CHEMBL4289921 | — | — | 1 | 7.00 |
| CHEMBL4283926 | — | — | 1 | 7.00 |
| CHEMBL4290069 | — | — | 1 | 7.00 |
| CHEMBL4281202 | — | — | 1 | 7.00 |
| CHEMBL4228384 | — | — | 1 | 7.00 |
| CHEMBL4228902 | — | — | 1 | 7.00 |
| CHEMBL4293252 | — | — | 1 | 7.00 |
| CHEMBL4227799 | — | — | 1 | 7.00 |
| CHEMBL4281159 | — | — | 1 | 6.00 |
| CHEMBL4288934 | — | — | 1 | 6.00 |
| CHEMBL4289695 | — | — | 1 | 6.00 |
| CHEMBL4287296 | — | — | 1 | 6.00 |
| CHEMBL4225358 | — | — | 1 | - |
| CHEMBL4287890 | — | — | 1 | - |
| CHEMBL4284863 | — | — | 1 | - |
| CHEMBL4277650 | — | — | 1 | - |
| CHEMBL4292495 | — | — | 1 | - |
| CHEMBL4286778 | — | — | 1 | - |
| CHEMBL4290497 | — | — | 1 | - |
| CHEMBL4277439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287561 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4288884 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4289921 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4283926 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4290069 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4281202 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4228384 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4228902 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4293252 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4227799 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4281159 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4288934 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4289695 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4287296 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4225358 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL4287890 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4284863 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4277650 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4292495 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4286778 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4290497 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4277439 | — | IC50 | > | 10000.0 | nM | - |