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Compound Detail

CHEMBL4293252

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O=C(O)c1ccnc(-n2nc(C3CC3)cc2O)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4293252
Phase Preclinical
Structure Type MOL
InChI Key WEZPYYZPYXGXHK-UHFFFAOYSA-N
2
Targets
10
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

245.2
MW (Da)
1.55
ALogP
5
HBA
2
HBD
88.2
PSA (Ų)
0.86
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H11N3O3
MW 245.24
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -1.21

Activity Summary

IC50 10 meas. best 7.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Lysine-specific demethylase 4A
CHEMBL5896
 IC50 7.26 6.608 55.0 5
Lysine-specific demethylase 4C
CHEMBL6175
 IC50 7.26 6.608 55.0 5

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Lysine-specific demethylase 4C IC50 = 55.0 nM 7.26 Activity Assay: The ability of test compounds to inhibit the activity of JMJD2C ... -
Lysine-specific demethylase 4A IC50 = 55.0 nM 7.26 Activity Assay: The ability of test compounds to inhibit the activity of JMJD2A ... -
Lysine-specific demethylase 4C IC50 = 100.0 nM 7.0 Inhibition of recombinant human N-terminal GST-tagged JMJD2C (2 to 372 residues)... -
Lysine-specific demethylase 4A IC50 = 100.0 nM 7.0 Inhibition of recombinant human N-terminal His-tagged JMJD2A (1 to 350 residues)... -
Lysine-specific demethylase 4C IC50 = 550.0 nM 6.26 JMJD2C Assay: The ability of test compounds to inhibit the activity of JMJD2C wa... -
Lysine-specific demethylase 4A IC50 = 550.0 nM 6.26 JMJD2A Assay: The ability of test compounds to inhibit the activity of JMJD2A wa... -
Lysine-specific demethylase 4C IC50 = 550.0 nM 6.26 JMJD2C Assay: The ability of test compounds to inhibit the activity of JMJD2C wa... -
Lysine-specific demethylase 4A IC50 = 550.0 nM 6.26 JMJD2A Assay: The ability of test compounds to inhibit the activity of JMJD2A wa... -
Lysine-specific demethylase 4C IC50 = 550.0 nM 6.26 In Vitro Enzyme Inhibition Assay: The ability of test compounds to inhibit the a... -
Lysine-specific demethylase 4A IC50 = 550.0 nM 6.26 In Vitro Enzyme Inhibition Assay: The ability of test compounds to inhibit the a... -

Data from ChEMBL 36 via Core Engine